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pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery

Pourjavadi, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.msec.2019.110418
  3. Publisher: Elsevier Ltd , 2020
  4. Abstract:
  5. Herein, a novel type of multifunctional magnetic nanoparticles with dual thermal and pH-responsive behavior was fabricated as the carrier for delivery of doxorubicin (DOX). Fe3O4@SiO2 magnetic nanoparticles, were grafted with polymer brushes consisting of poly (NIPAM-co-GMA) (PNG) chains via surface initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization. The polymer brushes were then modified with hydrazine groups as DOX binding sites. The prepared multifunctional magnetic nanoparticles were characterized by FT-IR, 1H NMR, XPS, TGA, DLS, VSM, GPC, TEM, and XRD analysis. The in vitro drug release of the multifunctional magnetic nanoparticles was examined at 37 °C (above LCST) and 25 °C (below LCST) in different pH media and exhibited excellent pH- and thermo-sensitive behavior. The results show that the Fe3O4@SiO2@PNG-Hy fabricated via SI-RAFT polymerization is a viable candidate material for tumor treatment studies. © 2019
  6. Keywords:
  7. Magnetic nanocarrier ; Nanoparticles ; pH- and thermo-sensitive ; SI-RAFT polymerization ; Binding sites ; Dendrimers ; Drug delivery ; Electronic guidance systems ; Iron oxides ; Living polymerization ; Magnetite ; Nanomagnetics ; Nitrogen compounds ; Nuclear magnetic resonance ; Silica ; SiO2 nanoparticles ; Targeted drug delivery ; Candidate materials ; Carrier for deliveries ; Magnetic nano-particles ; RAft polymerization ; Reversible addition fragmentation chain transfer ; Surface-initiated ; Thermo sensitive ; Controlled drug delivery ; Acrylic acid resin ; Magnetite nanoparticle ; Nanocomposite ; Poly-N-isopropylacrylamide ; Chemistry ; Infrared spectroscopy ; Nuclear magnetic resonance spectroscopy ; PH ; Physiology ; Acrylic Resins ; Cell Survival ; Doxorubicin ; Humans ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Magnetite Nanoparticles ; Nanocomposites ; Polymerization ; Silicon Dioxide ; Spectroscopy, Fourier Transform Infrared
  8. Source: Materials Science and Engineering C ; Volume 108 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0928493119314328