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Drug loading onto ion-exchange microspheres: Modeling study and experimental verification

Abdekhodaie, M. J ; Sharif University of Technology | 2006

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  1. Type of Document: Article
  2. DOI: 10.1016/j.biomaterials.2006.02.011
  3. Publisher: 2006
  4. Abstract:
  5. A new mathematical model was developed and an exact analytical solution without approximations of previous work was derived for the description of the kinetics and equilibrium characteristics of drug loading from a finite external solution onto ion-exchange microspheres. The influence of important parameters pertinent to material properties and loading conditions on the kinetics, efficiency, and equilibrium of drug loading was analyzed using the developed model and equations. The numerical results showed that the rate of drug loading increased with increasing initial drug concentration in the solution or with the relative volume of the external solution and the microsphere. The maximum binding capacity of the micrsophere and the association rate constant had positive effects on the loading rate and the equilibrium loading. A decrease in microsphere radius or an increase in drug diffusion coefficient accelerated the loading process but did not influence the equilibrium drug loading. The model prediction agreed with experimental results of verapamil hydrochloride loading onto sulfopropyl dextran microspheres. The usefulness of the model in the design of loading experiments for desired drug loading efficiency and equilibrium loading was demonstrated by numerical analysis. © 2006 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Concentration (process) ; Diffusion ; Mathematical models ; Drug loading kinetics ; Equilibrium loading and efficiency ; Exact analytical solution ; Experimental verification ; Ion-exchange microspheres ; Drug products ; Microsphere ; Verapamil ; Drug diffusion ; Equilibrium constant ; Kinetics ; Mathematical model ; Molecular model ; Priority journal ; Biocompatible Materials ; Diffusion ; Drug Carriers ; Ion Exchange ; Ion Exchange Resins ; Materials Testing ; Microspheres ; Models, Theoretical ; Particle Size ; Pharmaceutical Preparations
  8. Source: Biomaterials ; Volume 27, Issue 19 , 2006 , Pages 3652-3662 ; 01429612 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0142961206001633