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The effect of protein corona on doxorubicin release from the magnetic mesoporous silica nanoparticles with polyethylene glycol coating

Pourjavadi, A ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1007/s11051-015-3008-3
  3. Publisher: Kluwer Academic Publishers , 2015
  4. Abstract:
  5. In the present work, biocompatible superparamagnetic iron oxide nanoparticles coated by mesoporous silica were used as drug nanocarriers for doxorubicin (Dox; an anticancer drug) delivery. In biological media, the interaction of protein corona layer with the surface of nanoparticles is inevitable. For this reason, we studied the effect of protein corona on drug release from magnetic mesoporous silica nanoparticles (MMSNs) in human plasma medium. Besides, we used hydrophilic and biocompatible polymer, polyethylene glycol (PEG), to decrease protein corona effects. The results showed the increased Dox release from PEGylated MMSNs compared with bare MMSNs. This result indicated that the coating of PEG reduced the wrapping of the protein corona around the nanoparticles. This phenomenon caused increase in Dox release
  6. Keywords:
  7. Doxorubicin ; Mesoporous silica ; Nanomedicine ; Protein corona ; Super paramagnetic iron oxide nanoparticles ; Biocompatibility ; Coatings ; Iron oxides ; Magnetoplasma ; Medical nanotechnology ; Mesoporous materials ; Metal nanoparticles ; Nanoparticles ; Polyethylene glycols ; Polyethylenes ; Proteins ; Silica ; Biocompatible polymer ; Biological media ; Iron oxide nanoparticle ; Magnetic mesoporous silicas ; Nanomagnetics ; Macrogol ; Magnetic nanoparticle ; Silica nanoparticle ; Comparative study ; Controlled study ; Drug coating ; Drug delivery system ; Drug release ; Human ; Hydrophilicity ; Plasma ; Priority journal ; Protein interaction ; Surface property
  8. Source: Journal of Nanoparticle Research ; Volume 17, Issue 4 , April , 2015 ; 13880764 (ISSN)
  9. URL: http://link.springer.com/article/10.1007%2Fs11051-015-3008-3