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Optimal magnetic field for crossing super-para-magnetic nanoparticles through the Brain Blood Barrier: A computational approach

Pedram, M. Z ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.3390/bios6020025
  3. Publisher: MDPI AG , 2016
  4. Abstract:
  5. This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain. Furthermore, a weak magnetic portable stimulator can be developed using low complexity prototyping techniques. Based on MD simulation results in this paper, SPMNs can cross the cell membrane while experiencing very weak mechanical forces in the range of pN. This study also derives guidelines for the design of the SPMNs dedicated to crossing the BBB using external magnetic fields. © 2016 by the author
  6. Keywords:
  7. Blood Brain Barrier ; Force steering ; Molecular Dynamics simulation ; Superparamagnetic nanoparticles ; Magnetic nanoparticle ; Superparamagnetic nanoparticle ; Unclassified drug ; Article ; Capillary endothelium ; Electromagnetic radiation ; Endothelium cell ; Magnetic field ; Magnetism ; Mathematical analysis ; Mathematical model ; Membrane permeability ; Molecular dynamics ; Particle size ; Simulation ; Transcytosis
  8. Source: Biosensors ; Volume 6, Issue 2 , 2016 ; 20796374 (ISSN)
  9. URL: http://www.mdpi.com/2079-6374/6/2/25