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Electrospray: novel fabrication method for biodegradable polymeric nanoparticles for further applications in drug delivery systems

Zarrabi, A ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. Publisher: TANGER Ltd , 2009
  3. Abstract:
  4. Electrospray is an old processing technique that has recently been rediscovered. This technology is revolutionizing the biomaterials and nanotechnology fields by opening up new areas of research in fabricating drug delivery nano-devices. Due to their size, nanoparticles have the advantage of reaching less accessible sites in the body by escaping phagocytosis and entering tiny capillaries. Nanoparticles also have the unique property to accumulate at the site of inflammation and therefore, are very suitable for targeted drug delivery. The feasibility of fabricating relatively monodispersed polymeric nanoparticles by electrospray method in a modified electrospray setup is demonstrated in this study. The process comprises of dissolving desired polymer, in this study PLGA and PEG, in a volatile solvent, here acetonitril. The solution is then electrosprayed in the single cone-jet regime through a nozzle. After solvent evaporation during the path of which particles pave from the nozzle to collector, the fabricated nanoparticles can be collected in DI water which plays the role of surfactant for particles not letting them to aggregate. The results of SEM analysis clearly confirm the fabrication of monodispersed spherical polymeric nanoparticles with diameter range from 80 to 120 nm with smooth surface. The optimum processing variables of polymer concentration, voltage difference, and flow rate are 0.04 %w/v, 10 kV, and 0.01 ml/h for PLGA nanoparticles fabrication and 0.3 %w/v, 8 kV, and 0.01 ml/h for PEG nanoparticles fabrication. © 2009 TANGER Ltd
  5. Keywords:
  6. PLGA and PEG ; Polymer concentration ; SEM ; Spray mode ; Agglomeration ; Antigen-antibody reactions ; Biodegradable polymers ; Biological materials ; Copolymers ; Drug delivery ; Fabrication ; Nozzles ; Scanning electron microscopy ; Biodegradable polymeric nanoparticles ; Drug delivery system ; Electrospray method ; Polymer concentrations ; Polymeric nanoparticles ; Processing technique ; Solvent evaporation ; Targeted drug delivery ; Nanoparticles
  7. Source: NANOCON 2009 - 1st International Conference, Conference Proceedings ; 2009 , Pages 324-331 ; 9788087294130 (ISBN)
  8. URL: http://nanocon2014.tanger.cz/files/proceedings/nanocon_09/Lists/Papers/117.pdf