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Fabrication and properties of polycaprolactone composites containing calcium phosphate-based ceramics and bioactive glasses in bone tissue engineering: a review

Hajiali, F ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1080/15583724.2017.1332640
  3. Publisher: Taylor and Francis Inc , 2018
  4. Abstract:
  5. Polycaprolactone (PCL) is a bioresorbable and biocompatible polymer that has been widely used in long-term implants and controlled drug release applications. However, when it comes to tissue engineering, PCL suffers from some shortcomings such as slow degradation rate, poor mechanical properties, and low cell adhesion. The incorporation of calcium phosphate-based ceramics and bioactive glasses into PCL has yielded a class of hybrid biomaterials with remarkably improved mechanical properties, controllable degradation rates, and enhanced bioactivity that are suitable for bone tissue engineering. This review presents a comprehensive study on recent advances in the fabrication and properties of PCL-based composite scaffolds containing calcium phosphate-based ceramics and bioglasses in terms of porosity, degradation rate, mechanical properties, in vitro and in vivo biocompatibility and bioactivity for bone regeneration applications. The fabrication routes range from traditional methods such as solvent casting and particulate leaching to novel approaches including solid free-form techniques. © 2018 Taylor & Francis Group, LLC
  6. Keywords:
  7. Bioactive glasses ; Calcium phosphate-based ceramics ; Composite scaffolds ; Polycaprolactone ; Bioactive glass ; Biocompatibility ; Biomechanics ; Bone ; Calcium ; Calcium compounds ; Calcium phosphate ; Cell adhesion ; Cell engineering ; Ceramic materials ; Controlled drug delivery ; Degradation ; Drug delivery ; Fabrication ; Glass ; Mechanical properties ; Polymeric implants ; Scaffolds (biology) ; Tissue ; Biocompatible polymer ; Bone tissue engineering ; Composite scaffolds ; Controllable degradation ; Controlled drug release ; Fabrication routes ; Hybrid biomaterials ; Particulate leaching ; Tissue engineering
  8. Source: Polymer Reviews ; Volume 58, Issue 1 , 2018 , Pages 164-207 ; 15583724 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/15583724.2017.1332640