Loading...

Development of a novel carboxamide-based off-on switch fluorescence sensor: Hg2+, Zn2+and Cd2+

Kiani, M ; Sharif University of Technology | 2020

774 Viewed
  1. Type of Document: Article
  2. DOI: 10.1039/d0nj02595j
  3. Publisher: Royal Society of Chemistry , 2020
  4. Abstract:
  5. Here, the carboxamide ligand N-(thiazole-2-yl) picolinamide (L) was synthesized in an ionic liquid tetrabutylammonium bromide (TBAB) as the benign reaction medium. The sensitivity of L towards different metal-ions was investigated, and a comprehensive, logical optical investigation was conducted for the IIB transition metal ions, Hg2+, Cd2+ and Zn2+, based on off-on switch sensor protocols. In the absence of these metal ions, L showed weak emission only, but fluorescence intensity increased considerably upon their addition to a sensitivity range of 10-6 M. This phenomenon was enhanced significantly in the presence of Zn2+ compared to other metal ions, likely due to the coordination of metallic ions to the L, which led to the chelation-enhanced fluorescence (CHEF) effect. To prove these results, several characterization studies were conducted: a single crystal from the metal-ligand complex was prepared, followed by conduction of X-ray single crystal analysis from the Zn-complex (2) and Cd-complex (3), and conducting spectral analysis from the Zn2+, Hg2+ and Cd2+ complexes. These complexes and also the ligand showed very low toxicity on the PC12 cell line suggesting their promise for a wide range of future medical applications. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
  6. Keywords:
  7. Cell culture ; Complexation ; Ligands ; Medical applications ; Mercury compounds ; Metal ions ; Single crystals ; Spectrum analysis ; Transition metals ; Zinc compounds ; Characterization studies ; Enhanced fluorescence ; Fluorescence sensors ; Metal-ligand complexes ; Optical investigation ; Tetrabutylammonium bromide ; X-ray single-crystal analysis ; Cadmium compounds ; Amide ; Cadmium ; Ionic liquid ; Mercury ; Metal ion ; N (thiazole 2 yl)picolinamide ; Tetrabutylammonium ; Transition element ; Unclassified drug ; Zinc ion ; Chelation ; Comparative study ; Crystal structure ; Fluorescence ; Fluorescence intensity ; PC12 cell line (pheochromocytoma) ; Spectroscopy ; Synthesis ; X ray crystallography
  8. Source: New Journal of Chemistry ; Volume 44, Issue 27 , June , 2020 , Pages 11841-11852
  9. URL: https://pubs.rsc.org/en/content/articlelanding/2020/nj/d0nj02595j#!divAbstract