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Synthesis of magnesium-based Janus micromotors capable of magnetic navigation and antibiotic drug incorporation

Paryab, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1039/d0nj00537a
  3. Publisher: Royal Society of Chemistry , 2020
  4. Abstract:
  5. In the present study, bubble-driven magnesium-based micromotors were fabricated through a shading method, and the potential of magnetic guidance of magnesium-based Janus micro/nanomotors through functionalization with superparamagnetic iron oxide nanoparticles (SPIONs) was investigated for the first time. SPIONs had physical electrostatic attraction with the positively charged magnesium spheres due to negative charges on their surfaces. It was also found that upon applying a field gradient, the micromotors’ velocity increased by 13% unlike other magnetically navigated spherical magnesium-based micromotors which only show a change in direction. In this work the cytotoxicity of the moving magnesium-based micromotors was investigated for the first time and their cell viability corresponding to 100 μg ml−1was nearly 80%. Also, an antibacterial drug molecule was attached to the surfaces of the micromotors through direct conjugation. The drug attachment was confirmed by FTIR analysis and the drug loading capacity was also measured. The antibacterial activity of the moving micromotors reached nearly 100% inin vitromedium through drug conjugation. Furthermore, it was shown that their motile state was more bactericidal compared with their static state. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2020
  6. Keywords:
  7. Iron oxides ; Magnesium ; Magnetic nanoparticles ; Anti-bacterial activity ; Antibacterial drugs ; Drug loading capacity ; Electrostatic attractions ; Functionalizations ; Magnetic navigation ; Positively charged ; Superparamagnetic iron oxide nanoparticles ; Micromotors ; Ampicillin ; Magnetite nanoparticle ; Antibacterial activity ; Cell viability ; Comparative study ; Controlled study ; Cytotoxicity ; Drug conjugation ; Elemental analysis ; Hep-G2 cell line ; Human cell ; Hydrophilicity ; In vitro study ; Magnetic field ; PH ; Priority journal ; Surface property ; Synthesis ; Ultraviolet visible spectroscopy
  8. Source: New Journal of Chemistry ; Volume 44, Issue 17 , 2020 , Pages 6947-6957
  9. URL: https://pubs.rsc.org/en/content/articlelanding/2020/nj/d0nj00537a#!divAbstract