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Modeling of an ultrasound system in targeted drug delivery to abdominal aortic aneurysm: a patient-specificin silico study based on ligand-receptor binding

Shamloo, A ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1109/TUFFC.2021.3138868
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2022
  4. Abstract:
  5. Targeted drug delivery methods have shown a significant impact on enhancing drug delivery efficiency and reducing drug side effects. While various stimuli have been used to promote the drug delivery process, applying ultrasound (US) waves to control drug particles through the human body, noninvasively, has drawn the scientist's attention. However, microcarriers delivery reaches the aneurysmal artery by US waves that exert volumetric forces on blood, and drug carriers, which can therefore affect blood flow patterns and movement pathways of drug carriers, have not yet been studied. In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the effect of US waves in enhancing the drug-containing microbubbles (MBs) adhered on the AAA lumen through ligand-receptor binding. Thus, a focused US (FUS) transducer with a resonance frequency of 1.1 MHz was added to the geometry. Then, the surface density of MBs (SDM) adhered on the AAA lumen was calculated at peak acoustic pressure of 1.1, 2.2, and 4.3 MPa. Results indicated that increasing the US pressure had a significant impact on improving the MBs adhered to the intended wall, whereby US waves with the maximum pressure of 4.3 MPa could enhance 1- {mu } ext {m} MBs adhesion 98% relative to not using the waves. While US waves have the advantage of more SDM adhered to the whole artery wall, they adversely affect the SDM adhered on the critical wall of the abdominal aorta. Furthermore, when the US strength goes up, a reduction occurs in the SDM adhered. This reduction is higher for smaller MBs, which is the mentioned MBs' size and US strength reduced SDM adhesion by about 50% relative to systemic injection. Therefore, it can be concluded that drug delivery using the US field increases the SDM adhered to the whole AAA wall and decreases the SDM adhered to the critical wall of AAA. © 1986-2012 IEEE
  6. Keywords:
  7. Liganda receptor binding ; Microbubble (MB) ; Ultrasound (US) targeting ; 3D modeling ; Adhesion ; Blood ; Blood vessels ; Controlled drug delivery ; Drug interactions ; Ligands ; Targeted drug delivery ; Ultrasonics ; Abdominal aortic aneurysms ; Aneurysm lumen ; Artery ; Drug ; Drug carrier ; Ligand-receptor binding ; Microbubbles ; Surface density ; Ultrasound targeting ; Ultrasound waves ; Transducers ; Ligand ; Abdominal aorta ; Abdominal aortic aneurysm ; Diagnostic imaging ; Echography ; Human ; Microbubble ; Procedures ; Aorta, Abdominal ; Aortic Aneurysm, Abdominal ; Humans ; Ultrasonography
  8. Source: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ; Volume 69, Issue 3 , 2022 , Pages 967-974 ; 08853010 (ISSN)
  9. URL: https://ieeexplore.ieee.org/document/9663311