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Histidine-enhanced gene delivery systems: The state of the art

Hooshmand, S. E ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1002/jgm.3415
  3. Publisher: John Wiley and Sons Inc , 2022
  4. Abstract:
  5. Gene therapy has emerged as a promising tool for treating different intractable diseases, particularly cancer or even viral diseases such as COVID-19 (coronavirus disease 2019). In this context, various non-viral gene carriers are being explored to transfer DNA or RNA sequences into target cells. Here, we review the applications of the naturally occurring amino acid histidine in the delivery of nucleic acids into cells. The biocompatibility of histidine-enhanced gene delivery systems has encouraged their wider use in gene therapy. Histidine-based gene carriers can involve the modification of peptides, dendrimers, lipids or nanocomposites. Several linear polymers, such as polyethylenimine, poly-l-lysine (synthetic) or dextran and chitosan (natural), have been conjugated with histidine residues to form complexes with nucleic acids for intracellular delivery. The challenges, opportunities and future research trends of histidine-based gene deliveries are investigated. © 2022 John Wiley & Sons, Ltd
  6. Keywords:
  7. Gene delivery ; Macromolecules ; Nanomedicine ; Nucleic acid ; Ampholyte ; Cell penetrating peptide ; Chitosan ; Dendrimer ; Dextran ; Lipid ; Nanocomposite ; Peptide derivative ; Plasmid DNA ; Polyamidoamine ; Polyethyleneimine ; Polylysine ; Polymer ; Polypeptide ; Quantum dot ; Biocompatibility ; Chemical structure ; Complex formation ; Conjugation ; Endothelium cell ; Gene vector ; Genetic transfection ; Human ; Intracellular transport ; Macromolecule ; Nanomedicine ; Nonhuman ; Nonviral gene delivery system ; Nonviral gene therapy ; Protein modification ; Review ; Synthesis ; Gene transfer ; Genetics ; Therapy ; COVID-19 ; Gene Transfer Techniques ; Histidine ; Humans ; Nucleic Acids ; Transfection
  8. Source: Journal of Gene Medicine ; Volume 24, Issue 5 , 2022 ; 1099498X (ISSN)
  9. URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3415