Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults

Hassanvand, M. S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.envpol.2017.02.005
  3. Abstract:
  4. Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10(PM < 10 μm), PM2.5-10(PM 2.5–10 μm), PM2.5(PM < 2.5 μm), PM1-2.5(PM 1–2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013. Blood biomarkers were measured one every 7–8 weeks and included white blood cells (WBC), high sensitive C-reactive protein (hsCRP), tumor necrosis factor-soluble receptor-II (sTNF-RII), interleukin-6 (IL-6), and von Willebrand factor (vWF). We measured hourly indoor and outdoor exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1mass concentration to derive weighted averages of personal exposure based on simultaneously collected time-activity data. The random intercept linear mixed effects model was used for data analysis. We observed significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1; sTNF-RII with PM2.5, PM1-2.5, and PM1; hsCRP with PM2.5and PM1; and vWF with PM10and PM2.5-10, PM2.5, and PM1-2.5mass concentration in elderly subjects from the current-day and multiday averages. For healthy young adults, we found significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, and PM1-2.5, but no with PM1. The results showed that increase of hsCRP, sTNF-RII, and vWF were not significantly associated with any of the PM sizes investigated in the healthy young subjects. Our results provided some evidence that short-term exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1was associated with inflammation and coagulation blood markers, but associations were depended on PM size and also differed across the various time lag. © 2017 Elsevier Ltd
  5. Keywords:
  6. Circulating biomarkers ; Elderly panel ; Healthy young panel ; Biomarkers ; Blood ; Glycoproteins ; Particle size ; Linear mixed-effects model ; Particle-size fractions ; Systemic inflammation ; Tumor necrosis factors ; Pathology ; C reactive protein ; Tumor necrosis factor receptor 2 ; Von willebrand factor ; Air pollutant ; Biological marker ; C reactive protein ; IL6 protein, human ; Biomarker ; Cardiovascular disease ; Elderly population ; Health status ; Morbidity ; Mortality ; Panel data ; Pollution exposure ; Adolescent ; Aged ; Clinical article ; Controlled study ; Environmental exposure ; Human ; Inflammation ; Leukocyte ; Adverse effects ; Analysis ; City ; Comparative study ; Epidemiology ; Indoor air pollution ; Metabolism ; School ; Tehran [Iran] ; Tehran [Tehran (PRV)] ; Air Pollutants ; Air Pollution, Indoor ; Cities ; Female ; Humans ; Interleukin-6 ; Iran ; Male ; Particulate Matter ; Risk ; Schools
  7. Source: Environmental Pollution ; Volume 223 , 2017 , Pages 695-704 ; 02697491 (ISSN)
  8. URL: https://www.sciencedirect.com/science/article/pii/S0269749116313094?via%3Dihub