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Reprint of: Extraction of fluoxetine from aquatic and urine samples using sodium dodecyl sulfate-coated iron oxide magnetic nanoparticles followed by spectrofluorimetric determination

Bagheri, H ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1016/j.aca.2011.10.033
  3. Publisher: 2012
  4. Abstract:
  5. A new method based on the combination of magnetic solid phase extraction (MSPE) and spectrofluorimetric determination was developed for isolation and preconcentration of fluoxetine form aquatic and biological samples using sodium dodecyl sulfate (SDS) coated Fe 3O 4 nanoparticles (NPs) as a sorbent. The unique properties of Fe 3O 4 NPs including high surface area and strong magnetism were utilized effectively in the MSPE process. Effect of different parameters influencing the extraction efficiency of fluoxetine including the amount of Fe 3O 4 and SDS, pH value, sample volume, extraction time, desorption solvent and time were optimized. Under optimized condition, the method was successfully applied to the extraction of fluoxetine from water and urine samples and absolute recovery amount of 85%, detection limit of 20μgL -1 and a relative standard deviation (RSD) of 1.4% were obtained. The method linear response was over a range of 50-1000μgL -1 with R 2=0.9968. The relative recovery in different aquatic and urine matrices were investigated and values of 80% to 104% were obtained. The whole procedure showed to be conveniently fast, efficient and economical for extraction of fluoxetine from environmental and biological samples
  6. Keywords:
  7. Fe 3O 4 ; Biological samples ; Detection limits ; Extraction efficiencies ; Extraction time ; High surface area ; Linear response ; Magnetic solids ; Optimized conditions ; pH value ; Pre-concentration ; Relative standard deviations ; Sample volume ; Sodium dodecyl sulfate ; Spectrofluorimetric determination ; Spectrofluorimetry ; Urine analysis ; Urine sample ; Body fluids ; Desorption ; Iron oxides ; Nanomagnetics ; Nanoparticles ; Optimization ; pH effects ; Sodium ; Sodium sulfate ; Water analysis ; Solvent extraction ; Dodecyl sulfate sodium ; Fluoxetine ; Iron oxide magnetic nanoparticle ; Magnetic nanoparticle ; Unclassified drug ; Aquatic environment ; Drug determination ; Drug isolation ; Limit of detection ; Magnetic solid phase extraction ; Priority journal ; Process optimization ; Solid phase extraction ; Spectrofluorometry ; Urinalysis ; Water sampling
  8. Source: Analytica Chimica Acta ; Volume 716 , February , 2012 , Pages 61-65 ; 00032670 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0003267011014139