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Doxorubicin hydrochloride - loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers for hyperthermic tumor cell treatment and controlled drug release

Radmansouri, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.ijbiomac.2018.04.161
  3. Abstract:
  4. In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis. The DOX loading efficiency and in vitro drug release of DOX from nanofibers were investigated at both physiological and acidic conditions by an alternating of magnetic field and without magnetic field effect. The fastest release of DOX from prepared magnetic nanofibers was observed at acidic pH by alternating of magnetic field. The antitumor activity of synthesized nanofibers was also investigated on the melanoma cancer B16F10 cell lines. The obtained results revealed that the DOX loaded-electrospun chitosan/cobalt ferrite/titanium oxide nanofibers can be used for localized cancer therapy. © 2018 Elsevier B.V
  5. Keywords:
  6. Chemotherapy ; Doxorubicin hydrochloride ; Chitosan derivative ; Cobalt derivative ; Ferrite ; Titanium dioxide ; Antineoplastic agent ; Cobalt ferrite ; Ferric ion ; Nanofiber ; Nanoparticle ; Antineoplastic activity ; B16-F10 cell line ; Cancer chemotherapy ; Chemical analysis ; Controlled drug release ; Controlled study ; Drug effect ; Field emission scanning electron microscopy ; Hyperthermia ; In vitro study ; Magnetic field ; Microwave cooking ; Synthesis ; X ray diffraction ; Animal ; Chemistry ; Delayed release formulation ; Drug release ; Experimental melanoma ; Magnetism ; Mouse ; Pharmacology ; Procedures ; Tumor cell line ; Animals ; Antineoplastic agents ; Cell line, tumor ; Chitosan ; Cobalt ; Delayed-action preparations ; Doxorubicin ; Drug liberation ; Ferric compounds ; Magnetics ; Melanoma, experimental ; Mice ; Nanofibers ; Nanoparticles ; Temperature ; Titanium
  7. Source: International Journal of Biological Macromolecules ; Volume 116 , 2018 , Pages 378-384 ; 01418130 (ISSN)
  8. URL: https://www.sciencedirect.com/science/article/pii/S0141813018302319?via%3Dihub