Loading...

Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework

Hatamie, S ; Sharif University of Technology | 2019

1173 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.msec.2019.109862
  3. Publisher: Elsevier Ltd , 2019
  4. Abstract:
  5. Metal-organic framework (MOF) based graphene oxide (GO) recently merits of attention because of the relative correspondence of GO with metal ions and organic binding linkers. Furthermore, introducing the GO to the Co-MOF to make a new nanoporous hybrid have are improved the selectivity and stability of the Co-MOF. Here the graphene oxide/cobalt metal organic framework (GO/Co-MOF) was synthesized by a solvothermal process using cobalt salt and terephthalic acid and used for biocidal activity, against the growth of the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. X-ray diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy were confirmed the successful synthesize of metal organic framework and incorporation of Co-MOF in to GO sheets. Scanning electron microscopy was showed the cornflower structure of GO/Co-MOF, and transmission electron microscopy was confirmed, the Co-MOF are decorated on GO. Cytotoxicity study of GO/Co-MOF using 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) cell viability assay showed the biocompatibility to human fibroblasts cell over 72 h. The growth inhibition of the Escherichia coli and Staphylococcus aureus bacteria are reached over 99% for bacteria concentration of 100 μg/mL. The excellent antibacterial activity of GO based Co-MOF is linked to synergistic effect of sharp edges of the GO sheets and the toxic effect of cobalt ions (Co2+) which are released from their surfaces. The GO/Co-MOF radical scavenging assay was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) antioxidant assay for samples incubated with cells which confirmed the minimum radicals' toxicity on bacteria. This novel graphene oxide based MOF with its intrinsic superior porous structure, highly active metal coordination, and commercial linker, is an excellent promising candidate to use in biological and pharmaceutical applications as high potential sustained bactericidal materials. © 2019 Elsevier B.V
  6. Keywords:
  7. Antibacterial activity ; Cobalt ; Metal-organic framework ; Biocompatibility ; Biological materials ; Cell culture ; Cobalt ; Crystalline materials ; Fourier transform infrared spectroscopy ; Graphene ; Graphene oxide ; High resolution transmission electron microscopy ; Metal ions ; Metals ; Organometallics ; Scanning electron microscopy ; 1 ,1-diphenyl-2-picrylhydrazyl ; Anti-bacterial activity ; Antibacterial properties ; Bacteria concentrations ; Cell viability assays ; Metal organic framework ; Pharmaceutical applications ; Cobalt compounds ; 1,1-diphenyl-2-picrylhydrazyl ; Antiinfective agent ; Biphenyl derivative ; Cobalt ; Picric acid ; Chemistry ; Cytology ; Drug effect ; Fibroblast ; Human ; Microbial sensitivity test ; Nanopore ; Raman spectrometry ; Staphylococcus aureus ; Ultrastructure ; X ray diffraction ; Anti-Bacterial Agents ; Biphenyl Compounds ; Cobalt ; Escherichia coli ; Fibroblasts ; Graphite ; Humans ; Metal-Organic Frameworks ; Microbial Sensitivity Tests ; Nanopores ; Picrates ; Spectrum Analysis, Raman ; X-Ray Diffraction
  8. Source: Materials Science and Engineering C ; Volume 104 , 2019 ; 09284931 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0928493118327450