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Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes

Riahi, Z ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1088/2053-1591/ab6c98
  3. Publisher: Institute of Physics Publishing , 2019
  4. Abstract:
  5. Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer from all electrophoretically loaded TNT samples obeyed semi-infinite diffusion mechanism with a diffusion coefficient of 1.5 × 10-15 cm2 s-1. However, for bare specimens, external transfer prevailed. Anti-bacterial tests showed a bacteria-free region of 318 mm2 on the drug-loaded anodized samples during the initial stage of drug release; while 254 mm2 of bacteria-free region existed on the drug-loaded bare plates. Drug loading capacity of the anodized samples was enough for most biomedical applications. Ti6Al4V anodization proved a viable strategy for prosthesis drug loading and release. © 2020 IOP Publishing Ltd
  6. Keywords:
  7. Anodizing ; Electrophoretic method ; Ti6Al4V ; TiO2 nanotube ; Vancomycin antibiotic ; Anodic oxidation ; Bacteria ; Drug delivery ; Electrodes ; Medical applications ; Nanotubes ; Targeted drug delivery ; Ternary alloys ; Titanium dioxide ; Biomedical applications ; Drug loading capacity ; Electrophoretic methods ; Semi-infinite diffusion ; Storage capacity ; Ti-6al-4v ; TiO2 nanotubes ; Vancomycin ; Controlled drug delivery
  8. Source: Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; https://iopscience.iop.org/article/10.1088/2053-1591/ab6c98
  9. URL: https://iopscience.iop.org/article/10.1088/2053-1591/ab6c98