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Extraction of hydroxyapatite nanostructures from marine wastes for the fabrication of biopolymer-based porous scaffolds

Gheysari, H ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.3390/md18010026
  3. Publisher: MDPI AG , 2020
  4. Abstract:
  5. Three-dimensional porous nanocomposites consisting of gelatin-carboxymethylcellulose (CMC) cross-linked by carboxylic acids biopolymers and monophasic hydroxyapatite (HA) nanostructures were fabricated by lyophilization, for soft-bone-tissue engineering. The bioactive ceramic nanostructures were prepared by a novel wet-chemical and low-temperature procedure from marine wastes containing calcium carbonates. The effect of surface-active molecules, including sodium dodecyl sulfate (SDS) and hexadecyltrimethylammonium bromide (CTAB), on the morphology of HA nanostructures is shown. It is demonstrated that highly bioactive and monophasic HA nanorods with an aspect ratio > 10 can be synthesized in the presence of SDS. In vitro studies on the bioactive biopolymer composite scaffolds with varying pore sizes, from 100 to 300 μm, determine the capacity of the developed procedure to convert marine wastes to profitable composites for tissue engineering. © 2019 by the authors
  6. Keywords:
  7. Biopolymer ; Cytotoxicity ; Marine waste ; Tissue engineering ; Calcium carbonate ; Carboxylic acid derivative ; Carboxymethylcellulose ; Cetrimide ; Dodecyl sulfate sodium ; Hydroxyapatite ; Molecular scaffold ; Nanomaterial ; Porous polymer ; Nanocomposite ; Animal shell ; Article ; Bone tissue ; Ceramics ; Chemical procedures ; Chemical structure ; Controlled study ; Cross linking ; Extraction ; Freeze drying ; In vitro study ; Low temperature procedures ; Marine biowaste ; Nanofabrication ; Pore size ; Synthesis ; Waste ; Wet chemical procedure ; Chemistry ; Human ; Procedures ; Tissue scaffold ; Tumor cell line ; Biopolymers ; Carboxymethylcellulose Sodium ; Cell Line, Tumor ; Durapatite ; Gelatin ; Humans ; Nanocomposites ; Porosity ; Tissue Engineering ; Tissue Scaffolds
  8. Source: Marine Drugs ; Volume 18, Issue 1 , 2020
  9. URL: https://www.mdpi.com/1660-3397/18/1/26