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Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment

Rabiee, N ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jhazmat.2021.127130
  3. Publisher: Elsevier B.V , 2022
  4. Abstract:
  5. Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like K+ in the inner and middle ear may permanently damage the ear system. We synthesized nanoplatforms based on Allium noeanum to take the first steps in developing biological porous nanomembranes for hazardous cation detection in biological media. The 1,1,1-tris[[(2′-benzyl-amino-formyl)phenoxy]methyl]ethane (A), 4-amino-benzo-hydrazide (B), and 4-(2-(4-(3-carboxy-propan-amido)benzoyl)hydrazineyl)-4-oxobutanoic acid (B1) were synthesized to obtain green ligands based on 4-X-N-(…(Y(hydrazine-1-carbonyl)phenyl)benzamide, with X denoting fluoro (B2), methoxy (B3), nitro (B4), and phenyl-sulfonyl (B5) substitutes. The chemical structure of ligand-decorated adenosine triphosphate (ATP) molecules (S-ATP) was characterized by FTIR, XRD, AFM, FESEM, and TEM techniques. The cytotoxicity of the porous membrane was patterned by applying different cell lines, including HEK-293, PC12, MCF-7, HeLa, HepG2, and HT-29, to disclose their biological behavior. The morphology of cultured cells was monitored by confocal laser scanning microscopy. The sensitivity of S-ATP to different cations of Na+, Mg2+, K+, Ba2+, Zn2+, and Cd2+ was evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES) in terms of extraction efficiency (η). For pH of 5.5, the η of A-based S-ATP followed the order Na+ (63.3%) > Mg2+ (62.1%) > Ba2+ (7.6%) > Ca2+ (5.5%); while for pH of 7.4, Na+ (37.0%) > Ca2+ (33.1%) > K+ (25.7%). The heat map of MTT and dose-dependent evaluations unveiled acceptable cell viability of more than 90%. The proposed green porous nanomembranes would pave the way to use multifunctional green porous nanomembranes in biological membranes. © 2021 Elsevier B.V
  6. Keywords:
  7. Green chemistry ; Green synthesis ; Membrane ; Amides ; Atomic emission spectroscopy ; Biocompatibility ; Cell culture ; Diagnosis ; Electrophoresis ; Fourier transform infrared spectroscopy ; Inductively coupled plasma ; Ligands ; Nanostructures ; Phosphates ; Positive ions ; Adenosine triphosphate ; Benzamides ; Biological properties ; Ca 2+ ; Cell viability ; Green-chemistry ; Health-related problems ; Nanomembranes ; Synthesised ; Sustainable chemistry ; Benzamide ; Cadmium ; Calcium ion ; Carbonyl derivative ; Magnesium ion ; Sodium ion ; Succinic semialdehyde ; Zinc ion ; Benzamide derivative ; Cation ; Concentration (composition) ; Detection method ; Inorganic compound ; Pollutant removal ; Separation ; Allium ; Biomembrane ; Confocal laser scanning microscopy ; Heat ; Inductively coupled plasma atomic emission spectrometry ; Nanomembrane ; Nonhuman ; Separation technique ; Synthesis ; Transmission electron microscopy ; HEK293 cell line ; Human ; Allium noeanum ; Cations ; HEK293 Cells ; Humans ; Porosity ; Sodium
  8. Source: Journal of Hazardous Materials ; Volume 423 , 2022 ; 03043894 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0304389421020987