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Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin

Pourjavadi, A ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfb.2013.12.048
  3. Abstract:
  4. A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release
  5. Keywords:
  6. Dendrimer ; Drug delivery ; Magnetic nanoparticle ; PH-responsive nanocarrier ; Colloidal Stability ; Controlled delivery ; Magnetic nano-particles ; Magnetic nanocarrier ; Magnetic targeting ; Nanocarriers ; Polyamidoamine dendrimers ; Superparamagnetic iron oxide nanoparticles ; Dendrimers ; Loading ; Hydrazone derivative ; Macrogol ; Nanocarrier ; Polyamidoamine ; Polyethylene glycol dimethyl ester ; Superparamagnetic iron oxide nanoparticle ; Unclassified drug ; Drug carrier ; PAMAM Starburst ; Chemical structure ; Controlled drug release ; Covalent bond ; Drug stability ; pH ; Priority journal ; Chemistry ; Colloid ; Particle size ; Surface property ; Antineoplastic Agents ; Colloids ; Drug Carriers
  7. Source: Colloids and Surfaces B: Biointerfaces ; Vol. 116 , April , 2014 , pp. 49-54 ; ISSN: 09277765
  8. URL: http://www.sciencedirect.com/science/article/pii/S0927776513008035