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Synthesis of pseudopolyrotaxanes-coated superparamagnetic Iron oxide nanoparticles as new MRI contrast agent

Hosseini, F ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfb.2012.10.035
  3. Publisher: 2013
  4. Abstract:
  5. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of α-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem® and can be considered as a novel MRI contrast agent
  6. Keywords:
  7. MRI contrast agent ; Nanomedicine ; Hybrid nanomaterials ; MRI contrast agents ; Polyrotaxanes ; SPIONs ; Super molecules ; Drug delivery ; Medical imaging ; Medical nanotechnology ; Metal nanoparticles ; Nanostructured materials ; Superparamagnetism ; Synthesis (chemical) ; Alpha cyclodextrin ; Macrogol ; Nuclear magnetic resonance imaging agent ; Polymer ; Pseudopolyrotaxane ; Superparamagnetic iron oxide ; Superparamagnetic iron oxide nanoparticle ; Unclassified drug ; Chemical interaction ; Contrast ; Controlled study ; Dispersion ; In vitro study ; Material coating ; Nanotechnology ; Nuclear magnetic resonance imaging ; Priority journal ; Proton nuclear magnetic resonance ; Coated Materials, Biocompatible ; Contrast Media ; Cyclodextrins ; Dextrans ; Hydrophobic and Hydrophilic Interactions ; Magnetic Resonance Imaging ; Magnetite Nanoparticles ; Microscopy, Atomic Force ; Nanostructures ; Poloxamer ; Polyethylene Glycols ; Rotaxanes ; Spectroscopy, Fourier Transform Infrared
  8. Source: Colloids and Surfaces B: Biointerfaces ; Volume 103 , March , 2013 , Pages 652-657 ; 09277765 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0927776512005929