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Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: set the bugs to work?

Farjadian, F ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1016/j.biotechadv.2018.02.016
  3. Publisher: Elsevier Inc , 2018
  4. Abstract:
  5. Drug delivery is a rapidly growing area of research motivated by the nanotechnology revolution, the ideal of personalized medicine, and the desire to reduce the side effects of toxic anti-cancer drugs. Amongst a bewildering array of different nanostructures and nanocarriers, those examples that are fundamentally bio-inspired and derived from natural sources are particularly preferred. Delivery of vaccines is also an active area of research in this field. Bacterial cells and their components that have been used for drug delivery, include the crystalline cell-surface layer known as “S-layer” bacterial ghosts, bacterial outer membrane vesicles, and bacterial products or derivatives (e.g. spores, polymers, and magnetic nanoparticles). Considering the origin of these components from potentially pathogenic microorganisms, it is not surprising that they have been applied for vaccines and immunization. The present review critically summarizes their applications focusing on their advantages for delivery of drugs, genes, and vaccines. © 2018 Elsevier Inc
  6. Keywords:
  7. Bacterial ghosts ; Immunization, S-layer ; Nanomedicine ; Bacteria ; Cell membranes ; Controlled drug delivery ; Drug interactions ; Drug products ; Immunization ; Medical nanotechnology ; Microorganisms ; Nanomagnetics ; Nanoparticles ; Polymers ; Targeted drug delivery ; Vaccines ; Bacterial components ; Bacterial ghosts ; Bacterial polymers ; Drug delivery system ; Endospores ; S-layers ; Drug delivery ; Bacterium ; Cell component ; Drug ; Gene transfer ; Medicine ; Nanotechnology ; Pathogen ; Polymer ; Spore ; Vaccine ; Bacteria (microorganisms)
  8. Source: Biotechnology Advances ; Volume 36, Issue 4 , 2018 , Pages 968-985 ; 07349750 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0734975018300387