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Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Rafati, N ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1080/02652048.2019.1669728
  3. Publisher: Taylor and Francis Ltd , 2019
  4. Abstract:
  5. Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml−1) and 5.09% at the highest concentration (200μgml−1). Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group
  6. Keywords:
  7. Anti-cancer ; Inclusion complex ; Nanosponge ; Solubility ; Cross linking reagent ; Curcumin ; Cyclodextrin derivative ; Pyromellitic dianhydride ; Unclassified drug ; Blood compatibility ; Controlled release formulation ; Controlled study ; Cytotoxicity ; Differential scanning calorimetry ; Fourier transform infrared spectroscopy ; Hemolysis ; Human ; Human cell ; MCF-7 cell line ; Nanoencapsulation ; NCTC clone 929 cell line ; Physical chemistry ; X ray diffraction
  8. Source: Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/02652048.2019.1669728?journalCode=imnc20