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Biocompatibility, osseointegration, antibacterial and mechanical properties of nanocrystalline Ti-Cu alloy as a new orthopedic material

Moniri Javadhesari, S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfb.2020.110889
  3. Publisher: Elsevier B.V , 2020
  4. Abstract:
  5. The demands for high-performance biomaterials are driving the development of new metallic alloys with improved mechanical and biological responses. In this study, a nanocrystalline Ti-Cu intermetallic alloy was prepared by a powder metallurgy route, and its application as an orthopedic material was evaluated by the microstructural, mechanical, corrosion, antibacterial, cytotoxicity and osseointegration examinations. Microstructural characterization revealed the formation of TiCu and Ti2Cu3 as major phases with 23 nm grain size in the structure of the alloy. The synthesized alloy exhibited ultra-high hardness of 10 GPa, acceptable toughness of 8.14 MPam1/2, a ∼98 % anti-bacterial rate against S. aureus and E. coli, excellent cell viability to MG-63 osteosarcoma cells, and high osteoblast formation rate, which indicate a great potential of this alloy for biomedical application. © 2020 Elsevier B.V
  6. Keywords:
  7. Antibacterial activity ; Biocompatibility ; Biomaterial ; Osseointegration ; Ti-Cu alloy ; Binary alloys ; Biomaterials ; Biomechanics ; Copper corrosion ; Escherichia coli ; Mechanical properties ; Medical applications ; Nanocrystalline alloys ; Nanocrystals ; Powder metallurgy ; Titanium alloys ; Anti-bacterial activity ; Biological response ; Biomedical applications ; Micro-structural characterization ; Orthopedic materials ; Osseointegration ; Ultra high hardness ; Copper alloys ; Alloy ; Copper ; Titanium ; Cell viability ; Controlled study ; Corrosion ; Cytotoxicity ; Hardness ; Mechanics ; Metallurgy ; MG-63 cell line ; Nonhuman ; Ossification ; Osteoblast ; Particle size ; Priority journal ; Staphylococcus aureus ; Synthesis
  8. Source: Colloids and Surfaces B: Biointerfaces ; Volume 189 , May , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0927776520301193