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Multifunctional conductive biomaterials as promising platforms for cardiac tissue engineering

Mousavi, A ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1021/acsbiomaterials.0c01422
  3. Publisher: American Chemical Society , 2021
  4. Abstract:
  5. Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell-cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for discussion. In the present review, we classify and summarize the unique properties of conductive biomaterials considered beneficial for cardiac tissue engineering. We attempt to cover recent advances in conductive biomaterials with a particular focus on their effects on cardiac cell functions and proposed mechanisms of action. Finally, current problems, limitations, challenges, and suggested solutions for applications of these biomaterials are presented. © 2021 American Chemical Society. All rights reserved
  6. Keywords:
  7. Biomechanics ; Cell signaling ; Cells ; Conducting polymers ; Cytology ; Heart ; Tissue ; Cardiac tissue engineering ; Cardio-vascular disease ; Cell-cell signaling ; Conductive Polymer ; Current problems ; Differentiated cells ; Electrical conductivity ; Intrinsic potential ; Cell engineering ; Bioceramics ; Biomaterial ; Carbon nanofiber ; Carbon nanotube ; Gold nanoparticle ; Graphene ; Melanin ; Poly(3,4 ethylenedioxythiophene) ; Polyaniline ; Polypyrrole ; Selenium ; Silver nanoparticle ; Unclassified drug ; Polymer ; Cardiac muscle cell ; Cardiovascular disease ; Cell function ; Electric conductance ; Electric conductivity ; Heart arrhythmia ; Heart conduction ; Heart tissue ; Human ; Priority journal ; Tissue engineering ; Hydrogel ; Biocompatible Materials ; Hydrogels ; Polymers
  8. Source: ACS Biomaterials Science and Engineering ; Volume 7, Issue 1 , 2021 , Pages 55-82 ; 23739878 (ISSN)
  9. URL: https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01422