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Niosomal formulation for antibacterial applications

Mehrarya, M ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1080/1061186X.2022.2032094
  3. Publisher: Taylor and Francis Ltd , 2022
  4. Abstract:
  5. Infection is a disease that is mainly caused by different Gram-negative and Gram-positive bacteria. Treatment of infections requires a considerable amount of antibiotics, which can cause serious damage to the patient's body. Delivering the antibiotic only to the site of infection can prevent these destructive effects, such as the destruction of the normal intestinal flora. The drug delivery system through carriers will take antibiotics into a part of the body involved in the disease. Niosome nanoparticles, which have been made from non-ionic surfactants, have been emerging as ideal drug/antibiotics delivery vehicles. Recently, niosome formulations have been targeted to reduce toxicity and increase accumulation at the target site. Niosomes have performed well in the treatment of local infections, delivery of ocular drugs, and coating of orthopaedic bone/dental implants. This research aimed to highlight the molecular structure and physicochemical properties of niosomes and covered its manufacturing methodologies. Then we critically review the literature on niosomes for the mechanism of drug release, the carrier to deliver antibiotics, and its clinical effectiveness against bacterial infections. © 2022 Informa UK Limited, trading as Taylor & Francis Group
  6. Keywords:
  7. Antibacterial ; Bone implants ; Dental implants ; Local infection ; Niosome ; Ocular drug delivery ; Orthopaedic ; Antibiotic agent ; Carbon dioxide ; Antiinfective agent ; Liposome ; Surfactant ; Bacterial infection ; Chemical analysis ; Chemical procedures ; Chemical structure ; Coating (procedure) ; Drug formulation ; Drug release ; Drug uptake ; Ether injection method ; Human ; In vitro study ; Lipid bilayer ; Microfluidization method ; Nanofabrication ; Nonhuman ; Particle size ; Physical chemistry ; Proniosomal method ; Reverse phase evaporation method ; Review ; Supercritical fluid ; Thin film (procedure) ; Thin film hydration method ; Ultrasound ; Zeta potential ; Chemistry ; Drug delivery system ; Procedures ; Anti-Bacterial Agents ; Drug Delivery Systems ; Drug Liberation ; Humans ; Liposomes ; Surface-Active Agents
  8. Source: Journal of Drug Targeting ; Volume 30, Issue 5 , 2022 , Pages 476-493 ; 1061186X (ISSN)
  9. URL: https://www.tandfonline.com/doi/pdf/10.1080/1061186X.2022.2032094