Glassy carbon electrode modified with a bilayer of multi-walled carbon nanotube and polypyrrole doped with new coccine: Application to the sensitive electrochemical determination of Sumatriptan

Shahrokhian, S ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1016/j.electacta.2011.08.102
  3. Publisher: 2011
  4. Abstract:
  5. A promising electrochemical sensor was developed based on a layer by layer process by electro-polymerization of pyrrole in the presence of new coccine (NC) as dopant anion on the surface of the multi-walled carbon nanotubes (MWCNTs) pre-coated glassy carbon electrode (GCE). The modified electrode was used as a new and sensitive electrochemical sensor for voltammetric determination of sumatriptan (SUM). The electrochemical behavior of SUM was investigated on the surface of the modified electrode using linear sweep voltammetry (LSV). The results showed a remarkable increase (∼12 times) in the anodic peak current of SUM in comparison to the bare GCE. The effect of experimental variables such as, drop size of the casted MWCNTs suspension, pH of the supporting electrolyte, accumulation conditions and the number of cycles in the electro-polymerization process on the electrode response was investigated. Under the optimum conditions, the modified electrode showed a wide linear dynamic range of 0.02-10.0 μmol L-1 with a detection limit of 6 nmol L-1 for the voltammetric determination of SUM. The prepared electrode showed high sensitivity, stability and good reproducibility in response to SUM. This sensor was successfully applied for the accurate determination of trace amounts of SUM in pharmaceutical and clinical preparations
  6. Keywords:
  7. Anodic peaks ; Bi-layer ; Detection limits ; Drop size ; Electrochemical behaviors ; Electrochemical determination ; Electrode response ; Glassy carbon electrodes ; High sensitivity ; Layer by layer ; Linear dynamic ranges ; Linear sweep voltammetry ; Modified electrodes ; New coccine ; Number of cycles ; Optimum conditions ; Reproducibilities ; Sumatriptan ; Supporting electrolyte ; Trace amounts ; Voltammetric determination ; Chemical detection ; Doping (additives) ; Electrochemical sensors ; Electrodes ; Glassy carbon ; Multiwalled carbon nanotubes (MWCN) ; pH effects ; Polymerization ; Polypyrroles ; Sensors ; Trace analysis ; Voltammetry ; Glass membrane electrodes
  8. Source: Electrochimica Acta ; Volume 56, Issue 27 , November , 2011 , Pages 10032-10038 ; 00134686 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0013468611013491