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Synthesis of folate-modified, polyethylene glycol-functionalized gold nanoparticles for targeted drug delivery

Asadishad, B ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1080/01932690903213113
  3. Abstract:
  4. The chemical synthesis and in vitro drug delivery response of folate-modified, polyethylene glycol-functionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently, the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate-modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV-vis spectrometer was 80%. Drug release experiments displayed a controlled-release behavior that most of the conjugated doxorubicin was released within the first 12 hours
  5. Keywords:
  6. Folic acid ; Gold nanoparticles ; Lysine ; Polyethylene glycol (peg) ; Anti-cancer agents ; Chemical synthesis ; Controlled release ; Doxorubicin ; Drug release ; Folic acids ; Functionalizations ; Functionalized ; In-vitro ; Loading efficiency ; Targeted drug delivery ; TEM ; UV-Vis spectrometer ; Amino acids ; Drug delivery ; Fourier transform infrared spectroscopy ; Gold ; Nanoparticles ; Organic acids ; Polyethylene oxides ; Scanning electron microscopy ; Synthesis (chemical) ; Thermoplastics ; Transmission electron microscopy ; Polyethylene glycols
  7. Source: Journal of Dispersion Science and Technology ; Volume 31, Issue 4 , 2010 , Pages 492-500 ; 01932691 (ISSN)
  8. URL: http://www.tandfonline.com/doi/abs/10.1080/01932690903213113?journalCode=ldis20