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Synthesis of nanostructured Ag@SiO2-Penicillin from high purity Ag NPs prepared by electromagnetic levitation melting process

Malekzadeh, M ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1016/j.msec.2019.04.083
  3. Publisher: Elsevier Ltd , 2019
  4. Abstract:
  5. Nanostructured Ag@SiO2-Penicillin was synthesized from high-purity Ag0 NPs with a mean particle size of about 10 nm produced by electromagnetic levitation gas condensation (ELGC) method. The silver and penicillin contents of the synthesized nano-antibiotic were about 34 wt% and 2.5 wt% respectively, as determined by ICP-OES and TGA analyses. The antibacterial properties and synergistic effects of nanostructured Ag@SiO2 and Ag@SiO2–Penicillin on killing the Methicillin-susceptible S. aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) bacteria were also examined. The nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Ag@SiO2-Penicillin NPs showed an outstanding antibacterial activity compared to Penicillin and Ag@SiO2 NPs. The Fractional inhibitory concentration (FIC) indexes were 0.54 and 0.52 against MSSA and MRSA bacteria respectively, illustrating the synergistic effects of Ag@SiO2-Penicillin NPs. In addition, Ag@SiO2-Penicillin NPs showed promising dose-dependent cytotoxicity effects indicating the protective effects emanating from anti-inflammatory properties of penicillin. © 2019 Elsevier B.V
  6. Keywords:
  7. Penicillin ; Synergistic effect ; Bacteria ; Drug products ; Electromagnetic propulsion ; High resolution transmission electron microscopy ; Levitation melting ; Nanoparticles ; Particle size analysis ; Silica ; Silver nanoparticles ; Anti-bacterial activity ; Anti-inflammatories ; Antibacterial properties ; Cytotoxicity effects ; Electromagnetic levitation ; Inhibitory concentration ; Silver compounds ; Nanomaterial ; Penicillin derivative ; Silicon dioxide ; Cell death ; Chemistry ; Drug effect ; Electromagnetism ; Human ; Infrared spectroscopy ; Methicillin resistant Staphylococcus aureus ; Microbial sensitivity test ; Procedures ; Static electricity ; Synthesis ; Ultrastructure ; X ray diffraction ; Cell Survival ; Electromagnetic Phenomena ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Nanostructures ; Nanotechnology ; Particle Size ; Penicillins ; Silver ; Spectroscopy, Fourier Transform Infrared ; Thermogravimetry ; X-Ray Diffraction
  8. Source: Materials Science and Engineering C ; Volume 102 , 2019 , Pages 616-622 ; 09284931 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S092849311833697X