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Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural-like cells

Esmaeili, E ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1002/jcp.28040
  3. Publisher: Wiley-Liss Inc , 2019
  4. Abstract:
  5. While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe 2 O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators. © 2019 Wiley Periodicals, Inc
  6. Keywords:
  7. Magnetoelectric ; Mesenchymal stem cells ; Neural differentiation ; Scaffold ; Cobalt chloride ; Graphene oxide ; Magnetic nanoparticle ; Molecular scaffold ; Nanofiber ; Nanosheet ; Polyvinylidene fluoride ; Adipose tissue ; Article ; Cell differentiation ; Cell growth ; Cell isolation ; Dispersion ; Electrospinning ; Human ; Human cell ; Human cell culture ; Mesenchymal stem cell ; MTT assay ; Nerve cell ; Piezoelectricity ; Priority journal ; Real time polymerase chain reaction ; Scanning electron microscopy ; Synthesis ; Tissue engineering
  8. Source: Journal of Cellular Physiology ; Volume 234, Issue 8 , 2019 , Pages 13617-13628 ; 00219541 (ISSN)
  9. URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.28040