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Doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive Co-delivery system for chemo-photothermal therapy

Khafaji, M ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.2147/IJN.S226254
  3. Publisher: Dove Medical Press Ltd , 2019
  4. Abstract:
  5. Introduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy. Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol (6 kDa) and carboxylate-methoxy polyethylene glycol (6 kDa) to improve their stability, biocompatibility, and drug loading capability. Doxorubicin (DOX) and cisplatin (CDDP) were loaded on the PS-IONs through the interactions between the drug molecules and polyethylene glycol. Results: The PS-IONs demonstrated excellent cellular uptake, cytocompatibility, and hemocompatibility at the practical dosage. Furthermore, in addition to being an appropriate MRI agent, PS-IONs demonstrated superb photothermal property in 0.5 W/cm2 of 808 nm laser irradiation. The release of both drugs was effectively triggered by pH and NIR irradiation. As a result of the intracellular combination chemotherapy and 10 min of safe power laser irradiation, the highest cytotoxicity for iron-based nanocarriers (97.3±0.8%) was achieved. Conclusion: The results of this study indicate the great potential of PS-IONs as a multifunctional targeted co-delivery system for cancer theranostic application and the advantage of employing proper combination therapy for cancer eradication. © 2019 Khafaji et al
  6. Keywords:
  7. Chemo/photothermal therapy ; Control release ; Dual-drug delivery ; Iron oxide nanoparticles ; Superparamagnetic iron oxide nanoparticle ; Antineoplastic agent ; Contrast medium ; Macrogol ; Magnetite nanoparticle ; Blood clotting ; Breast cancer cell line ; Cancer cell ; Cancer control ; Cell culture ; Cell transfer ; Cell viability ; Combination chemotherapy ; Controlled study ; Cytotoxicity ; Drug dose ; Drug effect ; Drug interaction ; Drug release ; Drug stability ; Human ; Human cell ; In vitro study ; Irradiation ; Nuclear magnetic resonance imaging ; PH ; Photon correlation spectroscopy ; Photothermal therapy ; Physical chemistry ; Radiation exposure ; Transmission electron microscopy ; Vibrating sample magnetometry ; X ray diffraction ; Animal ; Breast tumor ; Chemistry ; Drug delivery system ; Laser ; MCF-7 cell line ; Mouse ; Multimodality cancer therapy ; Procedures ; Thermotherapy ; Animals ; Antineoplastic Agents ; Breast Neoplasms ; Cisplatin ; Combined Modality Therapy ; Contrast Media ; Doxorubicin ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hydrogen-Ion Concentration ; Hyperthermia, Induced ; Lasers ; Magnetic Resonance Imaging ; Magnetite Nanoparticles ; MCF-7 Cells ; Mice ; Phototherapy ; Polyethylene Glycols
  8. Source: International Journal of Nanomedicine ; Volume 14 , 2019 , Pages 8769-8786 ; 11769114 (ISSN)
  9. URL: https://www.dovepress.com/doxorubicincisplatin-loaded-superparamagnetic-nanoparticles-as-a-stimu-peer-reviewed-article-IJN