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Review on alzheimer's disease: inhibition of amyloid beta and tau tangle formation

Ashrafian, H ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.ijbiomac.2020.11.192
  3. Publisher: Elsevier B.V , 2021
  4. Abstract:
  5. It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which is known as the most common cause of dementia, is one of the top medical care concerns across the world. Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Aβ) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going to review studies that targeted inhibition of amyloid plaque and tau protein tangle formation, to suppress or postpone AD. © 2020 Elsevier B.V
  6. Keywords:
  7. 2 (2,4 dichlorophenyl) 3 (1 methyl 3 indolyl)maleimide ; 3 hydroxyindole ; Amyloid beta protein ; Amyloid precursor protein ; Aspidospermine ; Benzofuran derivative ; Bisphenol derivative ; Capreomycin ; Chir 98014 ; Cholic acid ; Congo red ; Curcumin ; Cyanocobalamin ; Cycloserine ; Dihydroxybenzoic acid derivative ; Dithiothreitol ; DM Tau protein ; Dobutamine ; Epigallocatechin gallate ; Ferulic acid ; Glutathione ; Glycogen synthase kinase 3 inhibitor ; Gossypetin ; Hypericin ; IA5p protein ; Indole derivative ; Lithium ; Methylene blue ; Microtubule associated protein ; Myricetin ; Natural product ; Nitrophenol ; Norapomorphine ; Oleocanthal ; OR1 protein ; OR2 protein ; Polyphenol ; Ppi 368 ; Ppi 433 ; Ppi 457 ; Pyrazinamide ; Pyridazine derivative ; Resveratrol ; Rifamycin derivative ; Rs 0466 ; Srn 003556 ; Tideglusib ; Unclassified drug ; Valproic acid ; Vitamin K group ; Y10A peptide ; Protein aggregate ; Tau protein ; Alzheimer disease ; Amyloid plaque ; Apple ; Blueberry ; Coffee ; Ginkgo biloba ; Grape ; Human ; Mulberry ; Neurofibrillary tangle ; Nonhuman ; Paeonia suffruticosa ; Papaya ; Pomegranate ; Protein aggregation ; Protein misfolding ; Review ; Strawberry ; Uncaria rhynchophylla ; Walnut ; Withania somnifera ; Disease predisposition ; Genetics ; Metabolism ; Pathology ; Proteinosis ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Disease Susceptibility ; Humans ; Neurofibrillary Tangles ; Plaque, Amyloid ; Protein Aggregates ; Protein Aggregation, Pathological ; Protein Folding ; Tau Proteins
  8. Source: International Journal of Biological Macromolecules ; Volume 167 , 2021 , Pages 382-394 ; 01418130 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0141813020351308