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Novel nano-porous hydrogel as a carrier matrix for oral delivery of tetracycline hydrochloride

Bardajee, G. R ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.colsurfa.2011.09.014
  3. Abstract:
  4. A novel nano-porous hydrogel (NPH) was synthesized via graft copolymerization of sodium acrylate (Na-AA) and acrylamide (AAm) onto salep backbones and its application as a carrier matrix for oral delivery of tetracycline hydrochloride (TH) was investigated. The Taguchi method as a strong experimental design tool was used for synthesis optimization. The swelling behavior of optimum hydrogel was measured in various media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermogravimetrical analysis (TGA). The study of the surface morphology of the hydrogels using SEM and AFM showed a nanoporous (average pore size: 180. nm) structure for the sample obtained under optimized conditions. The drug delivery results demonstrated that this NPH could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be a good candidate as an orally administrated drug delivery system
  5. Keywords:
  6. Acrylamides ; AFM ; Carrier matrix ; Graft copolymerization ; Hydrogel formation ; Nano-porous ; Optimized conditions ; Oral delivery ; Salep ; Sodium acrylates ; Swelling behavior ; Synthesis optimization ; Taguchi ; Tetracycline hydrochloride ; Acrylic monomers ; Amides ; Copolymerization ; Drug delivery ; Fourier transform infrared spectroscopy ; Grafting (chemical) ; Optimization ; Sodium ; Taguchi methods ; Hydrogels ; Acrylamide ; Drug carrier ; Nano porous hydrogel ; Nanomaterial ; Porous polymer ; Sodium acrylic acid ; Tetracycline ; Unclassified drug ; Chemical structure ; Controlled study ; Drug delivery system ; Experimental design ; Hydrogel ; Infrared spectroscopy ; Molecular size ; Polymerization ; Priority journal ; Scanning electron microscopy ; Synthesis ; Taguchi method ; Thermogravimetry
  7. Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects ; Volume 392, Issue 1 , December , 2011 , Pages 16-24 ; 09277757 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S0927775711005772