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Synthesis of a novel magnetic starch-alginic acid-based biomaterial for drug delivery

Forouzandehdel, S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.carres.2019.107889
  3. Publisher: Elsevier Ltd , 2020
  4. Abstract:
  5. The magnetic composite hydrogel was fabricated by the graft copolymerization of itaconic acid (IA) onto starch and Alginic acid in the presence graphene sheets (Gr) and Fe3O4 nanoparticles (Fe3O4@Gr-IA/St-Alg) for Guaifenesin (GFN) delivery and wound healing. The Fe3O4@Gr-IA/St-Alg biomaterial is a hydrogel network endowed the material with magnetic property. In addition, GFN not only achieved effectively bound to the magnetic hydrogel, but also released in a controlled manner. The using external magnetic field has significantly positive influence on the drug release rate. To close, these hydrogel drug carriers offer a favorable platform for magnetically targeted drug delivery as well as a dress for wound healing. © 2019 Elsevier Ltd
  6. Keywords:
  7. Drug release ; Magnetic nanocomposite ; Responsive hydrogel ; Controlled drug delivery ; Drug products ; Graft copolymers ; Grafting (chemical) ; Graphene ; Hydrogels ; Iron oxides ; Magnetite ; Nanomagnetics ; Sodium alginate ; Starch ; Drug release ; External magnetic field ; Fe3O4 nanoparticles ; Graft co polymerizations ; Guaifenesin ; Magnetic composites ; Magnetic nanocomposites ; Responsive hydrogels ; Targeted drug delivery ; Alginic acid ; Epichlorohydrin ; Growth hormone ; Iron nanoparticle ; Itaconic acid ; Magnetic nanoparticle ; Magnetic starch ; Unclassified drug ; Animal experiment ; Animal model ; Article ; Chemical analysis ; Clinical effectiveness ; Clinical evaluation ; Controlled study ; Cytotoxicity ; Drug delivery system ; Drug synthesis ; Hydrogel ; Magnetic field ; Male ; Mouse ; Nonhuman ; Polymerization ; Priority journal ; Wound healing
  8. Source: Carbohydrate Research ; Volume 487 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0008621519306214