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Perylene diimide-POSS network for semi selective solid-phase microextraction of lung cancer biomarkers in exhaled breath

Soufi, G ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.aca.2022.339550
  3. Publisher: Elsevier B.V , 2022
  4. Abstract:
  5. Lung cancer (LC) is the leading cause of cancer mortality so, the analysis of exhaled human breath has great significance for early non-invasive diagnosis. Poor selectivity and strong humidity are two bottlenecks for the application of gas sensors to exhaled breath analysis. The development of novel extractive phases for the analysis of exhaled breath by chromatography is therefore a lucrative object. Polyhedral oligomeric silsesquioxanes (POSS) are among the 3D porous materials whose unique properties make them promising coatings for solid-phase microextraction (SPME). Selective enrichment of polar or nonpolar targets depends on the pore size and functional groups on the POSSs. Herein, we disclosed 3D network of POSS-naphthalene diimide (POSS-NDI) and perylene diimide (POSS-PDI) as extractive phases for analysis of lung cancer biomarkers with the capability of capturing different volatile organic compounds (VOCs). The synthesized diimides were fully characterized by FT-IR, multinuclear NMR, SEM, TEM, TGA, and BET analysis. After optimization of all the influential parameters on sorption/desorption, figures of merit for three aldehydes as biomarkers of LC were obtained. The exhaled breath of twelve participants including seven healthy candidates and five cases with LC were examined. The partial least squares-discriminant analysis (PLS-DA) was implemented which led to the proper classification of healthy and LC patients with R2 calibration and cross-validation of 0.9738 and o.7882, respectively. © 2022 Elsevier B.V
  6. Keywords:
  7. POSSs ; Biological organs ; Diagnosis ; Discriminant analysis ; Diseases ; Extraction ; Least squares approximations ; Naphthalene ; Polycyclic aromatic hydrocarbons ; Pore size ; Porous materials ; Cancer biomarkers ; Cancer mortality ; Exhaled breath analysis ; Exhaled breaths ; Lung Cancer ; Perylene diimides ; Perylenediimides ; Polyhedral oligomeric silsesquioxanes ; POSS ; Solid-phase microextraction ; Volatile organic compounds ; Aldehyde ; Imide ; Naphthalene diimide ; Organosilicon derivative ; Perylene diimide ; Polyhedral oligomeric silsesquioxane ; Tumor marker ; Unclassified drug ; Volatile organic compound ; Biological marker ; Tumor marker ; Volatile organic compound ; Adult ; Breath analysis ; Brunauer Emmett Teller method ; Calibration ; Chemical structure ; Clinical article ; Comparative study ; Controlled study ; Cross validation ; Desorption ; Exhaled breath condensate ; Female ; Fourier transform infrared spectroscopy ; Human ; Lifespan ; Male ; Middle aged ; Nuclear magnetic resonance spectroscopy ; Partial least squares regression ; Process optimization ; Scanning electron microscopy ; Solid phase extraction ; Structure analysis ; Synthesis ; Thermogravimetry ; Transmission electron microscopy ; Infrared spectroscopy ; Lung tumor ; Mass fragmentography ; Procedures ; Solid phase microextraction ; Biomarkers ; Biomarkers, Tumor ; Breath Tests ; Gas Chromatography-Mass Spectrometry ; Humans ; Lung ; Lung Neoplasms ; Perylene ; Spectroscopy, Fourier Transform Infrared ; Volatile Organic Compounds
  8. Source: Analytica Chimica Acta ; Volume 1198 , 2022 ; 00032670 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0003267022001210