Loading...

Pyrolytic carbon coating for cytocompatibility of titanium oxide nanoparticles: A promising candidate for medical applications

Behzadi, S ; Sharif University of Technology | 2012

1926 Viewed
  1. Type of Document: Article
  2. DOI: 10.1088/0957-4484/23/4/045102
  3. Publisher: 2012
  4. Abstract:
  5. Nanoparticles for biomedical use must be cytocompatible with the biological environment that they are exposed to. Current research has focused on the surface functionalization of nanoparticles by using proteins, polymers, thiols and other organic compounds. Here we show that inorganic nanoparticles such as titanium oxide can be coated by pyrolytic carbon (PyC) and that the coating has cytocompatible properties. Pyrolization and condensation of methane formed a thin layer of pyrolytic carbon on the titanium oxide core. The formation of the PyC shell retards coalescence and sintering of the ceramic phase. Our MTT assay shows that the PyC-coated particles are cytocompatible at employed doses
  6. Keywords:
  7. Biological environments ; Biomedical use ; Ceramic phase ; Cytocompatibility ; Inorganic nanoparticle ; MTT assays ; Oxide nanoparticles ; Pyrolization ; Pyrolytic carbon ; Surface Functionalization ; Thin layers ; Coalescence ; Coatings ; Functional polymers ; Medical applications ; Nanoparticles ; Organic polymers ; Pyrolysis ; Sintering ; Titanium ; Titanium oxides ; Biomaterial ; Nanoparticle ; Titanium dioxide ; Chemistry ; Cytology ; Drug effect ; Fibroblast ; Medical technology ; Methodology ; Mouse ; Raman spectrometry ; Ultrastructure ; X ray diffraction ; Animals ; Biomedical Technology ; Carbon ; Cell Death ; Cell Line ; Cell Survival ; Coated Materials, Biocompatible ; Fibroblasts ; Methane ; Mice ; Nanoparticles ; Spectrum Analysis, Raman ; Temperature ; Thermogravimetry
  8. Source: Nanotechnology ; Volume 23, Issue 4 , 2012 ; 09574484 (ISSN)
  9. URL: http://iopscience.iop.org/article/10.1088/0957-4484/23/4/045102/meta