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Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering

Shamloo, A ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jbiotec.2015.08.005
  3. Publisher: Elsevier , 2015
  4. Abstract:
  5. This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal gradients of biochemical factors is attainable inside microdevices. Since biomaterials with tunable properties are a worthwhile option to construct artificial extracellular matrix, in vitro platforms that simultaneously utilize natural, synthetic, or engineered biomaterials inside microfluidic devices are phenomenally advantageous to experimental studies in the field of tissue engineering. Additionally, collaboration between experimental and computational methods is a useful way to predict and understand mechanisms responsible for complex biological phenomena. Computational results can be verified by using experimental platforms. Computational methods can also broaden the understanding of the mechanisms behind the biological phenomena observed during experiments. Furthermore, computational methods are powerful tools to optimize the fabrication of microfluidic devices and biomaterials with specific features. Here we present a succinct review of the benefits of microfluidic devices, biomaterial, and computational methods in the case of tissue engineering and regeneration medicine. Furthermore, some breakthroughs in biological phenomena including the neuronal axon development, cancerous cell migration and blood vessel formation via angiogenesis by virtue of the aforementioned approaches are discussed
  6. Keywords:
  7. Biomaterial ; Computational methods ; Extracellular matrix ; Microfluidic device ; Tissue engineering ; Biomaterials ; Blood vessels ; Computational methods ; Enzyme activity ; Fluidic devices ; Microfluidics ; Tissue ; Tissue regeneration ; Artificial extracellular matrixes ; Computational results ; Computational technique ; Engineered biomaterials ; Extracellular matrices ; Integrative utilization ; Micro-fluidic devices ; Regenerative medicine ; Tissue engineering ; Biomaterial ; Angiogenesis ; Biochemical composition ; Biological phenomena and functions concerning the entire organism ; Biotechnology ; Breast epithelium cell ; Cell differentiation ; Cell interaction ; Cell migration ; Cell motility ; Cell polarity ; Cell viability ; Cellular, subcellular and molecular biological phenomena and functions ; Experimental study ; Extracellular matrix ; Human ; In vitro study ; Microenvironment ; Nerve growth ; Phenotype ; Priority journal ; Protein degradation ; Regenerative medicine ; Review ; Specialization ; Tissue engineering ; Tissue interaction ; Tumor microenvironment
  8. Source: Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0168165615300857