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Aptamer hybrid nanocomplexes as targeting components for antibiotic/gene delivery systems and diagnostics: a review

Ahmadi, S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.2147/IJN.S248736
  3. Publisher: Dove Medical Press Ltd , 2020
  4. Abstract:
  5. With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs. © 2020 Rabiee et al
  6. Keywords:
  7. Antibiotic ; Gene delivery systems ; Hybrid nanocomplexes ; Targeting ; Antibiotic agent ; Aptamer hybrid nanocomplex ; Carbon nanotube ; DNA ; Epidermal growth factor receptor 2 ; Epithelial cell adhesion molecule ; Fluorescein ; Gold nanocluster ; Gold nanoparticle ; Macrogol ; Mesoporous silica nanoparticle ; MicroRNA ; Mucin 1 ; Nanocarrier ; Nanomaterial ; Neomycin ; Plasmid DNA ; Polylysine ; Protein bcl xl ; Single walled nanotube ; Small interfering RNA ; Unclassified drug ; Vancomycin ; Antiinfective agent ; Aptamer ; Nanoparticle ; Apoptosis ; Atomic absorption spectrometry ; Atomic emission spectrometry ; Cancer diagnosis ; Cancer therapy ; Circulating tumor cell ; DNA structure ; Drug absorption ; Drug targeting ; Fluorescence ; Francisella tularensis ; Gene delivery system ; Limit of detection ; MCF-7 cell line ; MDA-MB-231 cell line ; Molecular weight ; MOLT-4 cell line ; Nanomedicine ; Particle size ; Polymerase chain reaction ; Protein expression ; RNA interference ; Staphylococcus aureus ; Systematic evolution of ligands by exponential enrichment aptamer technique ; Transmission electron microscopy ; U266B1 cell line ; Ultraviolet visible spectroscopy ; Vibrio parahaemolyticus ; Western blotting ; X ray absorption spectroscopy ; X ray photoemission spectroscopy ; Zeta potential ; Chemistry ; Drug delivery system ; Gene transfer ; Ultrastructure ; Anti-Bacterial Agents ; Aptamers, Nucleotide ; Drug Delivery Systems ; Gene Transfer Techniques ; Humans ; Nanoparticles ; Polyethyleneimine
  8. Source: International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 4237-4256
  9. URL: https://www.dovepress.com/aptamer-hybrid-nanocomplexes-as-targeting-components-for-antibioticgen-peer-reviewed-article-IJN