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Graphene-based nanomaterials in fighting the most challenging viruses and immunogenic disorders

Ebrahimi, M ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1021/acsbiomaterials.1c01184
  3. Publisher: American Chemical Society , 2022
  4. Abstract:
  5. Viral diseases have long been among the biggest challenges for healthcare systems around the world. The recent Coronavirus Disease 2019 (COVID-19) pandemic is an example of how complicated the situation can get if we are not prepared to combat a viral outbreak in time, which brings up the need for quick and affordable biosensing platforms and vast knowledge of potential antiviral effects and drug/gene delivery opportunities. The same challenges have also existed for nonviral immunogenic disorders. Nanomedicine is considered a novel candidate for effectively overcoming these worldwide challenges. Among the versatile nanomaterials commonly used in biomedical applications, graphene has recently earned much attention thanks to its special and inspiring physicochemical properties, such as its large surface area, efficient thermal/electrical properties, carbon-based chemical purity with controllable biocompatibility, easy functionalization, capability of single-molecule detection, anticancer characteristics, 3D template feature in tissue engineering, and, in particular, antibacterial/antiviral activities. In this Review, the most important and challenging viruses of our era, such as human immunodeficiency virus, Ebola, SARS-CoV-2, norovirus, and hepatitis virus, and immunogenic disorders, such as asthma, Alzheimer's disease, and Parkinson's disease, in which graphene-based nanomaterials can effectively take part in the prevention, detection, treatment, medication, and health effect issues, have been covered and discussed. © 2021 American Chemical Society
  6. Keywords:
  7. Antiviral effects ; Ebola ; HIV ; Parkinson's/Alzheimer's prevention ; SARS-CoV-2 ; Biocompatibility ; Chemical detection ; Graphene ; Medical nanotechnology ; Nanostructured materials ; Neurodegenerative diseases ; Physicochemical properties ; Tissue engineering ; Alzheimer ; Anti-viral drugs ; Anti-viral effects ; Biosensing platforms ; Drug/gene delivery ; Healthcare systems ; Parkinson/alzheimer prevention ; Viral disease ; Coronavirus ; 6 carboxyfluorescein ; Acetylcholine ; Acetylcholinesterase ; Alpha synuclein ; Amyloid beta protein ; Angiotensin converting enzyme 2 ; Antioxidant ; Apomorphine ; Aptamer ; Ascorbic acid ; Beta galactosidase ; Boron nitride ; Bovine serum albumin ; Cabergoline ; Carbon ; Carbon fiber ; Carbon nanotube ; Caspase 8 ; Dauricine ; Donepezil ; Dopamine ; Fluorescein ; Gallium ; Glycoprotein ; Gold nanoparticle ; Graphene oxide ; Hepatitis B surface antigen ; Horseradish peroxidase ; Immunoglobulin E ; Immunoglobulin G ; Indium ; l 3 4 dihydroxyphenyl alanine ; Malonaldehyde ; Monoclonal antibody ; Multi walled nanotube ; Nanocomposite ; Nanoplatelet ; Nanoribbon ; Nanosheet ; Nevirapine ; Nicotine ; Ovalbumin ; Pyridoxine ; Pyroxylin ; Quantum dot ; Riboflavin ; Rivastigmine ; RNA directed DNA polymerase inhibitor ; Superoxide dismutase ; Tenofovir ; Theophylline ; Tulobuterol ; Ubiquitin ; Unclassified drug ; Zinc oxide ; Nanomaterial ; Acquired immune deficiency syndrome ; Alpha tocopherol ; Alzheimer disease ; Amino terminal sequence ; Amperometry ; Antibacterial activity ; Antiviral activity ; Apoptosis ; Asthma ; Atomic force microscopy ; Carboxy terminal sequence ; Chronoamperometry ; Circular dichroism ; Computer assisted tomography ; Coronavirus disease 2019 ; Cytotoxicity ; Differential pulse voltammetry ; Drug delivery system ; Drug development ; Ebola hemorrhagic fever ; Ebolavirus ; EC50 ; Electric conductivity ; Environmental risk ; Enzyme linked immunosorbent assay ; Exhaled breath condensate ; Fluorescence resonance energy transfer ; Fourier transform infrared spectroscopy ; Gene delivery system ; Ginger root powder ; Hepatitis C virus ; Human immunodeficiency virus ; IC50 ; Impedance spectroscopy ; Limit of detection ; Liver fibrosis ; Molecular docking ; Nanomedicine ; Norovirus ; Nuclear magnetic resonance imaging ; Parkinson disease ; Plant product ; Raman spectrometry ; Refraction index ; Reverse transcription polymerase chain reaction ; Review ; Scanning electron microscopy ; Scanning tunneling microscopy ; Severe acute respiratory syndrome coronavirus 2 ; Surface plasmon resonance ; Upregulation ; Virus hepatitis ; Virus infection ; X ray diffraction ; Human ; Virus ; COVID-19 ; Graphite ; Humans ; Nanostructures ; SARS-CoV-2 ; Viruses
  8. Source: ACS Biomaterials Science and Engineering ; Volume 8, Issue 1 , 2022 , Pages 54-81 ; 23739878 (ISSN)
  9. URL: https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c01184